Bei Roche kannst du ganz du selbst sein und wirst für deine einzigartigen Qualitäten geschätzt. Unsere Kultur fördert persönlichen Ausdruck, offenen Dialog und echte Verbindungen. Hier wirst du für das, was du bist, wertgeschätzt, akzeptiert und respektiert. Dies schafft ein Umfeld, in dem du sowohl persönlich als auch beruflich wachsen kannst. Gemeinsam wollen wir Krankheiten vorbeugen, stoppen und heilen und sicherstellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und in Zukunft. Werde Teil von Roche, wo jede Stimme zählt.
Die Position
In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.
The Opportunity
Joining Small Molecule Research Discovery within Therapeutic Modalities, you will work within a highly engaged, cross-functional team bridging cell biology, automation, and multiple therapeutic areas. In this role, you drive innovation through strong commitment to lab science by developing the foundational cellular models that power our drug discovery pipeline.
Your key responsibilities include:
- Developing, optimizing, and validating robust cell-based functional assays—including complex 3D models—using technologies such as HTRF, AlphaLISA, Luminescence, and High-Content Imaging.
- Miniaturizing cellular assays into high-density plate formats (384-well and 1536-well plates), optimizing performance parameters such as Z’-factor and signal-to-background ratio.
- Maintaining, characterizing, and performing quality control on a wide range of mammalian cell lines, including primary cells, continuous lines, and induced pluripotent stem cells (iPSCs).
- Partnering closely with the High-Throughput Screening and Profiling team to seamlessly transfer new assays onto integrated robotic systems.
- Running routine cellular assays to generate high-quality data supporting structure-activity relationship (SAR) studies for portfolio projects.
- Analyzing complex screening datasets using modern scientific tools (e.g., Genedata Screener, Spotfire) and documenting workflows meticulously in Electronic Lab Notebooks (ELN).
- Serving as the primary cellular assay expert on multidisciplinary project teams, sharing insights across chemistry, High-Throughput Screening and Profiling, and therapeutic area groups.
Who You Are
You are a curious, highly motivated scientist who thrives on solving complex biological challenges. You bring a collaborative mindset, value diverse perspectives, and are eager to apply your expertise to discover life-changing treatments.
Qualifications and skills:
- Master’s degree in Cell Biology, Molecular Biology, or a closely related scientific discipline.
- 5+ years of relevant industry research experience focused on advanced cell culture and cell-based assay development.
- Demonstrated experience in miniaturizing assay workflows into 384- and 1536-well plate formats and utilizing automated liquid-handling systems.
- Strong proficiency in data analysis, statistical evaluation, and presenting scientific findings clearly to multidisciplinary teams.
- Fluency in English with strong interpersonal and communication skills.
- Flexibility and a resourceful problem-solving approach tailored to a dynamic lab environment.
- Nice to have: Hands-on experience with iPSC differentiation, 3D cellular models, or Design-of-Experiments (DoE) methodology.
How to Apply
Ready to join our team? Please submit the following documents: Updated CV, Cover Letter, Copy of your Higher Education Diploma
Please be advised that this position is 100% lab-based.
Wer wir sind
Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.
Gemeinsam können wir eine gesündere Zukunft gestalten.
Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.
